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本帖最后由 randomqd 于 2016-8-16 12:20 编辑
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1st Edition/ K5 w8 U( o' k+ M4 {! [0 w) T! n
Authors: Joo Chuan Tong Shoba Ranganathan
0 x! y0 E; E+ i/ I; z/ ?Electronic ISBN 9781908818416 Print ISBN 9781907568411
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( n. J3 U- w8 M3 _: tDescription% Q Y. j* J L3 D) G# s
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates./ V+ {2 K. _$ T, q0 \3 n+ T/ a
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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; J$ l! K- v" q" f" V$ `Table of Contents9 O. M1 z( }' i; T+ V/ e* H3 w6 i2 \8 T
List of figures
m: h0 ~! o2 ~( N- a# jList of abbreviations
" g# q# {! ~ z/ c+ K# x" {About the authors2 R/ T5 u u8 M" Y) p/ p" B
Preface
- g+ p8 g* C* s$ d* D, _% {$ kChapter 1: MHC and T cell responses$ O" o; |+ y+ O" O1 x7 h- M: V" V
Abstract:
9 g4 Y4 v |+ v) n5 |8 G, Y" M1.1 Genetic organization of the MHC
" d- a- V; C5 [0 {5 T1.2 MHC structure' L: K4 V+ E6 X1 k' V. Z
1.3 MHC function
6 s! v. q' c, e1.4 Peptide binding2 x1 s- [. l4 }1 W2 L
Chapter 2: Immunoglobulins and B cell responses- p: E% r% s# {5 Q
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2.1 Types of immunoglobulins% a' Z* d# p& b1 D* g4 J
2.2 Immunoglobulin structure
1 `1 X l, s8 A# m* h" V2.3 Immunoglobulin function
6 W8 i T% V/ V/ v8 ]6 A7 D( r2.4 Antigen binding9 n) V$ y4 g) Q3 `
Chapter 3: Scientific publications and databases1 x9 H( |; K. i9 l0 U: _
Abstract:
0 q$ f; I |+ M$ B6 |8 C- J# u3.1 Bibliographical information" P8 [" `" K' S- Y4 y4 `
3.2 Searching the literature
9 `2 m. m$ r* f; j3.3 General databases containing information on genes and proteins
8 l+ c( o0 T* G4 y v3.4 Immunological databases$ }6 M: n0 y8 ?: c n
3.5 Small molecule databases" R* }) Z: r" M* P4 M9 D& t
Chapter 4: Database design
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4.1 Fundamentals of database design+ {2 I+ V1 h+ T2 J5 F0 s
4.2 ER diagram
" f. [2 b$ N9 _3 R% {8 ]4.3 Normalization and normal forms
) C6 M9 ?/ O& V0 E* s- HChapter 5: Computational T cell vaccine design/ u s \# V, d/ Z( C7 R1 _3 p
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5.1 Sequence-based methods
, `/ O# s, F* E; o0 h- v5.2 Structure-based methods9 m0 L# V4 s' q; Y5 b
5.3 Broad-based T cell vaccine design
2 q* M+ t" h* FChapter 6: Computational B cell vaccine design9 x" q. B9 c/ Z! `) Q
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6.1 Sequence-based methods
+ y8 H) ?" Y# S0 x9 V6.2 Structure-based methods
. [, j5 V# w* J D$ AChapter 7: Infectious disease informatics8 ^$ Z6 V9 F. u6 A* Y; G
Abstract:
( X. _' w9 e: |/ I3 x G8 E7.1 Infectious diseases in history
" ~" T: P% D0 r6 c; t. u. ]5 b& D7.2 Microbial sequence analysis
5 u: [9 y: }2 E- X; L7 r- t7.3 Detecting natural selection in molecular evolution1 \9 B, F, G2 I8 Z9 o$ H4 q
Chapter 8: Vaccine safety and quality assessments
2 L+ m, l1 d5 B; d0 LAbstract:
$ O" j$ Q: g/ R4 o* H8.1 Assessment of ADME/Tox deficiencies
# Y/ s, W% q- Z$ h0 V: E) o4 W8.2 Assessment of allergenicity- _! `; S5 t; V5 c Q
Chapter 9: Vaccine adjuvant informatics
, b5 |$ D; c7 VAbstract:3 `, I2 ~3 b+ c& J# ]
9.1 Virtual combinatorial library5 p. Y8 C' k8 N! l6 y% Y" s; r
9.2 Chemical file formats
$ C. j( A2 z! u& a' S) G: x9.3 Considerations for virtual library design3 m/ m, I+ _8 Y9 _" w* u
Index& ?: K4 ~& C) L
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发表于 2016-10-9 10:55:32
