|
|
本帖最后由 randomqd 于 2016-8-16 12:20 编辑 1 p. W( Z' m' T# M! x
4 w; x0 y' O. c9 y$ u, m& l+ Z5 K
1st Edition
/ H( y- g7 N- p" H; d8 I, ~Authors: Joo Chuan Tong Shoba Ranganathan* |' F" f$ Y+ m" W# p7 N- D
Electronic ISBN 9781908818416 Print ISBN 97819075684115 e0 C7 `' E* ~$ Z% p7 S8 i
% V' N+ H( [/ W3 ^; _! FDescription
7 s6 Q/ [$ M. uComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
0 L+ [) h J( a/ Z; ^5 w3 r" TComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
! O$ T6 U6 q3 }+ V& T6 H5 `& J4 `7 |% }& Z: S1 ?! t/ u
, @& u+ y& U6 p% y/ a* M+ @% Q E5 QTable of Contents
1 u* ] g+ u8 z; I" X5 S; N9 PList of figures7 M) T# r1 R. u
List of abbreviations7 l, X' C* r4 T1 F2 i
About the authors4 g9 I; K! T; ?" W+ n/ S! I0 z
Preface7 a) {' U+ T/ I; O; Z
Chapter 1: MHC and T cell responses
: } t& i5 b6 _6 C; Q: [Abstract:& l( ]' O% J$ h$ Y3 `$ o
1.1 Genetic organization of the MHC- `1 I* x) b6 r8 g; U/ v
1.2 MHC structure1 Y, w8 s1 R/ K# A
1.3 MHC function7 u8 U- o4 b5 e8 T( S N
1.4 Peptide binding
) H) i: S% e$ C' [$ d/ z# a( eChapter 2: Immunoglobulins and B cell responses
: E5 Y1 d% L+ ]; T$ `Abstract:( d: ^! v; q% F, B8 Q6 s
2.1 Types of immunoglobulins0 s& K" c Z" D5 P/ g0 g- P
2.2 Immunoglobulin structure
0 W' c. d( C" E& S+ \/ l( O2.3 Immunoglobulin function
+ ~7 k/ e2 p7 k/ j2.4 Antigen binding
9 U7 d+ n1 P6 e. S; s( r7 d. _Chapter 3: Scientific publications and databases
4 s4 j% A$ l1 V4 f Z7 aAbstract:
& e4 b2 T5 D" I0 z2 p3 ]& t3.1 Bibliographical information0 W8 b+ q* a/ z6 l0 s* B
3.2 Searching the literature- e( E; [4 W# \
3.3 General databases containing information on genes and proteins' T, ?$ ^3 ?/ ~- j! ?4 i, _
3.4 Immunological databases
7 p& @0 M. L& B3.5 Small molecule databases
. V- ~8 K6 O3 ?; F5 WChapter 4: Database design8 ~/ I w o0 u9 F' _
Abstract:
, i, p, }% W* i$ n1 C2 W3 ?( d" y4.1 Fundamentals of database design
9 s) j) U# |) v1 E. q4.2 ER diagram) |) q1 f/ X, `6 ~! f' O6 i! _" z
4.3 Normalization and normal forms0 Z* q0 A/ Y3 `- E
Chapter 5: Computational T cell vaccine design
: T) a/ R1 R# U' OAbstract:' J% P$ z+ i- t7 j" y- c- q
5.1 Sequence-based methods
1 v! X+ ^( z9 C8 M2 ? }/ P5.2 Structure-based methods: Y% m$ g- r/ z* y+ c
5.3 Broad-based T cell vaccine design) y1 \6 r. v4 Z0 S* c/ S4 _
Chapter 6: Computational B cell vaccine design
9 P) P+ q- {' ]: f- MAbstract:
, o- \; W" q, d/ f6.1 Sequence-based methods
/ O. M* `3 t. y9 G9 [6.2 Structure-based methods8 z" d `6 R# H. X3 ?- V
Chapter 7: Infectious disease informatics9 N v3 p- Q/ ?* A
Abstract:
( Q: u% ^: f- c @7.1 Infectious diseases in history
/ m+ G! y/ D6 l' w" m; _1 c7.2 Microbial sequence analysis
0 l" u9 x% g" n' b* c. R7.3 Detecting natural selection in molecular evolution1 i3 ?( k7 A8 Z' i
Chapter 8: Vaccine safety and quality assessments, r" ^) B0 [* h9 z3 g
Abstract:% w* M2 J4 _+ C8 n
8.1 Assessment of ADME/Tox deficiencies4 b# v* n& z3 A4 h
8.2 Assessment of allergenicity( ~( m5 U9 x+ X+ ^8 u$ p
Chapter 9: Vaccine adjuvant informatics
% I3 t& p2 Z! {, y1 x7 w+ O6 Q; EAbstract:
% H; Z4 ^. k! K, g/ N. F! A9.1 Virtual combinatorial library2 k3 D- W: @+ g7 m
9.2 Chemical file formats) W3 J5 K' V, o, L& H9 J, V
9.3 Considerations for virtual library design
, o' x% P% [% }6 q% ^( r. vIndex) D8 T+ I) E. w5 n* K8 D
% K! o- `, o f4 _$ z% y! v) _
1 @- @" b. j9 S3 M3 E" F1 Q
8 b- B* T/ I6 j( t- p3 m0 k原文下载地址：. b+ L. T2 S1 }1 s
) E( S! h" |/ E2 Q4 s8 b) e! L
, c1 Q. ], t$ w1 Q! e! _ |
本帖子中包含更多资源
您需要 登录 才可以下载或查看，没有账号？立即注册
×
|
发表于 2016-8-16 12:18:44
发表于 2016-10-9 10:55:32
