|
|
本帖最后由 randomqd 于 2016-8-16 12:20 编辑 ' ?$ R; N- }+ @+ W
D8 V' L2 U5 x' M3 A7 g& K1st Edition
$ k. n% ?9 l. P" OAuthors: Joo Chuan Tong Shoba Ranganathan$ k; L5 b2 t/ `+ ^- C
Electronic ISBN 9781908818416 Print ISBN 9781907568411
+ a# P U( H) Y3 q6 B. f9 M2 Q+ y# S! I0 z" i% U3 m: v& w
Description
. ^/ P# ^! {/ B. ^+ [; CComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
7 \( }& N6 }% V* dComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.8 S. Q0 d8 i: g" c8 Q: H
% `# x6 g8 X7 K3 y
5 A+ h" R. H4 S' x- c% d5 \ Q
Table of Contents
. i# t3 [: G& C% G$ b5 \List of figures7 u1 j; f3 k i' V: ^- X$ E
List of abbreviations
3 p+ k4 w4 P7 P- `4 _About the authors
, ?: W& \! I* k, K* _7 c/ hPreface' `# U+ |. C% a( D8 O
Chapter 1: MHC and T cell responses% b2 k% ?* K' [5 L' F: c$ y
Abstract:
. d2 s2 t3 W2 L1 G6 | [1.1 Genetic organization of the MHC0 P1 e4 y5 ?# M, {" k& B" U
1.2 MHC structure
g) I C& b; }+ I1.3 MHC function# }) J- S+ ?- \" R
1.4 Peptide binding
7 { Q" J" J+ Q. @2 m5 ~( n6 VChapter 2: Immunoglobulins and B cell responses
: R3 l* C! B( H' B2 N& b1 m- eAbstract:4 I; l2 m3 @4 H" a
2.1 Types of immunoglobulins" ?2 O& n: ]0 L, h
2.2 Immunoglobulin structure, F. q1 S$ n& Y+ K
2.3 Immunoglobulin function
% x# l M; C# o; `2 Z1 J2.4 Antigen binding/ G+ E5 ?' u& R% s0 a% f
Chapter 3: Scientific publications and databases- V9 J1 @* a6 o2 e/ H/ `
Abstract:
9 B+ b# n2 a9 K0 x% l# M- B3.1 Bibliographical information6 j: f# q9 e8 i4 h! W6 k2 [
3.2 Searching the literature
# {- }5 z9 I4 V9 v9 @! o$ ~4 {5 v3.3 General databases containing information on genes and proteins7 s+ \- h0 |# g
3.4 Immunological databases& H8 ^9 K6 m2 y
3.5 Small molecule databases$ J; ^+ d, a2 x
Chapter 4: Database design
4 ?$ I1 g2 C1 j( ^; |6 e; MAbstract:
# W% c3 P' R2 j0 a4.1 Fundamentals of database design
0 Y% x+ Q# L2 s4.2 ER diagram
- }0 I, L& B A, h1 H4.3 Normalization and normal forms! D: `4 K/ W( Q
Chapter 5: Computational T cell vaccine design
0 U& ^# S$ P! S2 A, Z0 T% UAbstract:0 |3 P" e" s2 u z
5.1 Sequence-based methods
2 |7 l3 b% I+ \4 P5.2 Structure-based methods
. y e: w: m" f$ b6 J5.3 Broad-based T cell vaccine design& h! u* E2 |. q5 a9 R$ J
Chapter 6: Computational B cell vaccine design, {7 n( z1 L2 S) n1 P" X: ~
Abstract:
- X# m& n- [3 G( L5 {, g6.1 Sequence-based methods7 l7 @+ G2 ~: O: S, I0 X
6.2 Structure-based methods
! Y: v( ~" _* x( rChapter 7: Infectious disease informatics
! Z; S; u# H0 l2 Y3 qAbstract:! w7 V9 i0 ]; G( h7 |7 c% M
7.1 Infectious diseases in history' @; X& A0 s7 j( t: A7 s2 p6 k
7.2 Microbial sequence analysis. L* ]7 O+ ?2 n! f H
7.3 Detecting natural selection in molecular evolution p+ A, |5 A& w' l
Chapter 8: Vaccine safety and quality assessments3 K# s& Q: W! j7 {
Abstract:
7 @4 p3 R+ X& ^3 ^1 V3 d& d. h8.1 Assessment of ADME/Tox deficiencies
q1 Y9 r4 f5 i* F4 U# |9 H) g8.2 Assessment of allergenicity
! s: ]" }# c% t& B7 O. IChapter 9: Vaccine adjuvant informatics
# K2 X0 L- G5 x' b+ q9 J+ j. tAbstract:
. e% Z4 v* f) |# V2 e9.1 Virtual combinatorial library3 @* C# M1 I5 X$ @
9.2 Chemical file formats
$ k% M" N7 C4 X- g! q9.3 Considerations for virtual library design3 v2 B2 n1 F! d3 x0 K9 z
Index
6 _. q& ` o$ |6 L O3 J! I1 d5 ~3 ^3 d7 C$ F7 B/ c
1 n& c, d3 ~+ L. P" V- r0 t- |) P& _: [( V& r
原文下载地址：+ D2 P X3 q4 o; \5 p, j9 R3 p/ H4 } b
3 f2 z. y9 z, {1 m0 X: O' t
) R6 i: X/ |' w |
本帖子中包含更多资源
您需要 登录 才可以下载或查看，没有账号？立即注册
×
|
发表于 2016-8-16 12:18:44
发表于 2016-10-9 10:55:32
