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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 $ `1 h4 d/ r8 p6 Q6 I
6 g" @ C" ?; i( \% x+ |# @1st Edition5 l4 {: S2 `6 ^+ @: g
Authors: Joo Chuan Tong Shoba Ranganathan8 k: R' L- m9 X+ G% a/ s: c9 `
Electronic ISBN 9781908818416 Print ISBN 9781907568411
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1 M8 l V. X L& ?9 m% UDescription3 t, H' y4 W3 U( s/ S( e8 n9 S
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.: o8 y* `; j) z6 C# H2 o/ `
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.7 s4 i4 G* Z' w( D# X/ c
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1 x0 }% j8 P# P! j4 |/ k! `Table of Contents6 K, C) h, a2 c
List of figures
8 H; Q( g0 R- k; w" h. UList of abbreviations* j2 z7 g" X) }% j: Q( y" I
About the authors0 P0 g8 B# p5 Q5 [9 D
Preface( j; x8 A4 `% q: o) C% V" o2 W S
Chapter 1: MHC and T cell responses$ L& A4 h6 e5 q! m7 R/ x
Abstract:
/ g9 k" l: m% t3 E4 C1.1 Genetic organization of the MHC& ~1 ~$ u: J M' s6 }" E/ ~
1.2 MHC structure# L7 Y( f- t8 G: l( x% }
1.3 MHC function9 O2 e( p6 D" d1 H
1.4 Peptide binding
6 S# w' I# L+ l9 a' NChapter 2: Immunoglobulins and B cell responses& \1 q, c9 k" r7 n6 {4 I, C
Abstract:7 ?3 g. C0 ]5 Q( f0 m! c. g- k$ ]
2.1 Types of immunoglobulins5 D6 h) ?# B' W9 n. r" r
2.2 Immunoglobulin structure
/ {+ I1 e# z3 S2 ]2.3 Immunoglobulin function
4 ^* p+ a& g- x: ?) l8 ^0 w2.4 Antigen binding6 I9 R0 K# `' V2 P2 O7 p, N1 ]
Chapter 3: Scientific publications and databases
) I- N- ?) d! KAbstract:
% R' {( d' J8 G8 u3.1 Bibliographical information- a c: | V" C/ V/ R7 B. [6 X4 ]
3.2 Searching the literature0 t: g5 f V- I% r5 W- C
3.3 General databases containing information on genes and proteins7 L6 |( S" {$ \& P8 V$ L
3.4 Immunological databases
: \# I* ~0 `- e$ P; p0 B) v% \3.5 Small molecule databases
2 p* ~, o* J$ v# W# a9 ]. \Chapter 4: Database design
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4.1 Fundamentals of database design; K) G( ]! M# P0 w0 _
4.2 ER diagram t( s: K$ p* z2 c. ]& E
4.3 Normalization and normal forms5 t1 L1 Y) r, L4 G
Chapter 5: Computational T cell vaccine design: M: }4 T, m: S) W, W. @
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5.1 Sequence-based methods3 T& ?4 L2 S" ?/ k" o
5.2 Structure-based methods
5 E( o) w+ _' Q! X. e: R/ l5.3 Broad-based T cell vaccine design
6 M) R# `- j* x- eChapter 6: Computational B cell vaccine design
" H. U% O. f2 K; F- z& _! @ U" @% M% FAbstract:
8 E, O9 f$ K. P; p: |- ]6.1 Sequence-based methods
; n9 W w0 N% E6 H D$ @& M6.2 Structure-based methods7 b, ]: _1 z4 [. f
Chapter 7: Infectious disease informatics3 V8 N, p( {$ R
Abstract:
/ t& U9 V' P7 ^+ W7.1 Infectious diseases in history- k4 N, [: {) U3 F# I& u) L2 r
7.2 Microbial sequence analysis
$ m/ b) p6 l: [7.3 Detecting natural selection in molecular evolution8 W" h. U5 w6 x7 S B# `9 w+ V
Chapter 8: Vaccine safety and quality assessments" @6 D' q, H1 }
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8.1 Assessment of ADME/Tox deficiencies+ O1 l/ t+ C/ q) }+ ?7 B
8.2 Assessment of allergenicity8 y/ `) p4 G2 z. O3 |$ @
Chapter 9: Vaccine adjuvant informatics
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* d! z" Q B$ {9.1 Virtual combinatorial library! d) W, X$ l: i9 p( Y3 ?
9.2 Chemical file formats
9 E) j) ]/ r/ p* A3 M4 ]9.3 Considerations for virtual library design
9 H2 z5 Y4 b, }$ B7 |/ q3 g. z. P/ HIndex! q- {7 e: ~8 U) A0 G
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发表于 2016-8-16 12:18:44
发表于 2016-10-9 10:55:32
