|
|
发表于 2015-11-18 09:34:55
|
显示全部楼层
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
# W4 D* ^; h: y( ?. k' c
, ~: L e1 O4 s c- f' ^) X Di Wang, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao & Linrong Lu! b9 o6 h# j) Q
( Z e8 q. A, ^. Y
Signaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.
( U# S& b! _( S( b! Y. R+ l* ?5 j c1 ~( A" o: n
鲁教授又出好文章了。 |
|
发表于 2015-11-18 11:04:50
