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发表于 2015-11-17 22:50:45 | 显示全部楼层 |阅读模式
http://www.nature.com/ni/journal/v13/n6/full/ni.2301.html顺便下一下补充的pdf. A' d+ u9 g$ X+ ?  N4 z% r

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发表于 2015-11-18 09:34:55 | 显示全部楼层
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
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Di Wang,        Mingzhu Zheng,        Lei Lei,        Jian Ji,        Yunliang Yao,        Yuanjun Qiu,        Lie Ma,        Jun Lou,        Chuan Ouyang,        Xue Zhang,        Yuewei He,        Jun Chi,        Lie Wang,        Ying Kuang,        Jianli Wang,        Xuetao Cao        & Linrong Lu
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1 K. F# u4 Z; M" @- FSignaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.% o3 D! N% A6 I5 p

- W8 y# ?1 T! X鲁教授又出好文章了。

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发表于 2015-11-18 11:04:50 | 显示全部楼层
文件有点大,留个邮箱吧,我发你

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 楼主| 发表于 2015-11-19 13:09:02 | 显示全部楼层
ipsvirus 发表于 2015-11-18 11:04
* t! b8 @2 u- B9 s- b4 R# e( Q文件有点大,留个邮箱吧,我发你

  ?* t. j+ k) U% f1455710563@qq.com,谢谢啦

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 楼主| 发表于 2015-11-19 13:09:44 | 显示全部楼层
marine0425030 发表于 2015-11-18 09:34* P7 z6 f9 Q& d: f2 S% I
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling( \: u5 Z7 H9 X  s6 ~6 R( W
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  ...

% g, J* J% L& N6 h未来的老板

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发表于 2015-11-19 13:17:49 | 显示全部楼层
zszhao 发表于 2015-11-19 13:091 e# H* e% ]2 l' R% h! |3 B
,谢谢啦

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