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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 ( w& R) i! ], ^+ s) o7 x
; |+ D* z' Z. h4 v9 c+ Q( o) [1st Edition
- |2 w; O3 x4 t3 U; CAuthors: Joo Chuan Tong Shoba Ranganathan
9 f# O0 Y& K, g( mElectronic ISBN 9781908818416 Print ISBN 9781907568411
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2 P: T" m6 o/ L6 I, ~6 qDescription
4 s/ S, F# A0 r" \0 K$ EComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
8 t7 d( y# m: Q! Y: \/ _Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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Table of Contents& t' f" a9 b( o- a0 `8 V
List of figures" d) H8 T1 F4 h: P& b/ H6 t
List of abbreviations8 x4 m7 A2 ^2 S* X& B. C8 g0 D: z
About the authors
( }( ]6 g- W9 f3 g; H7 H6 @Preface
! n( R5 i( K M x ]3 V# DChapter 1: MHC and T cell responses# Q. I$ b9 G, {+ O$ r
Abstract:
( G' p2 x" }$ f3 |1 {( Y) K1.1 Genetic organization of the MHC2 W4 E. R* q! q) I* f
1.2 MHC structure r7 l4 F6 A: R' H; h; |$ u; y
1.3 MHC function! B+ d! o! e5 f$ ^# C$ T
1.4 Peptide binding6 m; F+ p+ l9 c3 J2 ~0 c+ s
Chapter 2: Immunoglobulins and B cell responses4 j0 s+ K! k: Y
Abstract:
) }0 B a; h. P7 A. H2.1 Types of immunoglobulins5 C3 i8 n$ A2 n, @* l, A
2.2 Immunoglobulin structure
2 c. Q9 U3 i( v$ d e2.3 Immunoglobulin function" s/ m3 P, Z. x3 {/ H1 X% X
2.4 Antigen binding
* l, v; m; r; ?. Z1 FChapter 3: Scientific publications and databases; T1 {' ^0 X% O/ s% q, Z# r" l
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3.1 Bibliographical information- m0 x! f2 {+ }4 L. U5 e' V
3.2 Searching the literature. O$ c0 S% K# U/ u
3.3 General databases containing information on genes and proteins p: w; i% T! W" U
3.4 Immunological databases
- Q% {" [1 ^% j5 }5 q8 v* Y8 w3.5 Small molecule databases
% r$ k7 ]( y, d/ EChapter 4: Database design7 i" S4 k! {9 V6 [
Abstract:/ y! v! {! z% ]
4.1 Fundamentals of database design6 v; k9 c: S3 d- |1 [
4.2 ER diagram
6 \8 d$ Q& C7 g4.3 Normalization and normal forms
( B& \5 @: ? S# {- F, M% s- v: SChapter 5: Computational T cell vaccine design2 F* O: O6 ?( j' M" I/ U
Abstract:
( g1 ]& N! s4 Q5 ~5.1 Sequence-based methods6 G) @. v2 g- Q& m, `2 O8 z; F
5.2 Structure-based methods' t% `( v6 {" s$ C8 D( a' A8 }
5.3 Broad-based T cell vaccine design2 }& L& k# d% ^5 n! K
Chapter 6: Computational B cell vaccine design& J3 {, P7 _5 K. v5 _4 S
Abstract:
4 L `( j6 ]' _) r! _6.1 Sequence-based methods; I, ~* p' ~: C8 `
6.2 Structure-based methods
$ I" H2 R C5 H/ `" X2 ~Chapter 7: Infectious disease informatics
( b6 g) ~+ b$ a* ?3 _Abstract:
( z% y5 a. {( l$ L1 x7.1 Infectious diseases in history( u6 {2 F0 i6 S" |% B
7.2 Microbial sequence analysis8 _, q% {/ F- J. X2 ^3 O7 e- j
7.3 Detecting natural selection in molecular evolution1 K( b) C" c9 q9 U* H
Chapter 8: Vaccine safety and quality assessments* K* n- a$ c8 \& {& Y
Abstract:
1 b4 n9 _. B/ q& x8.1 Assessment of ADME/Tox deficiencies
! W" B `6 l( v& Q+ ?4 ^ K8.2 Assessment of allergenicity
# b( S' Z; H& v+ ~0 ^' P" ~( aChapter 9: Vaccine adjuvant informatics/ g9 K/ |1 @$ l3 I' [- @1 c9 `
Abstract:
" w0 ~7 x* F1 I. H: c; D$ u4 H1 K9.1 Virtual combinatorial library) S0 p- X {( D
9.2 Chemical file formats, p5 r2 A; @" h4 p3 x# _
9.3 Considerations for virtual library design$ j/ s. c- h6 M) T
Index
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发表于 2016-8-16 12:18:44
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发表于 2016-10-9 10:55:32
