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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 - k: r( ~; F8 H' ~ c
" [0 q6 a$ ^) v% q& E8 W/ n$ {1st Edition0 r& {) ]3 L/ m0 u+ A# s& Y7 P/ t2 Q
Authors: Joo Chuan Tong Shoba Ranganathan
- k9 P7 E- J; E& |1 @Electronic ISBN 9781908818416 Print ISBN 9781907568411
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Description
- Q! \ u$ X$ h& N4 {Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.: K* b$ c" [& ~# N# g+ d% m
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.8 n0 Z) W& W! I, F( ~6 d$ j! \
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Table of Contents
& w3 v) F' N) M" M3 dList of figures
* E- S0 v2 H, Y$ b8 D/ gList of abbreviations4 z, h# k9 G2 ]9 i# Z* @4 g
About the authors6 @1 ?4 h7 \: `' i: l
Preface7 T% F+ R- h8 \: B! o
Chapter 1: MHC and T cell responses ^0 @9 Y3 w+ P
Abstract:
! v1 k! w, s! q. h2 T2 I1.1 Genetic organization of the MHC
9 a" @4 t# a- |1 k# o1 @' H6 ~3 w1.2 MHC structure
, }; n# h* U3 D; b1.3 MHC function
* N3 ~* l, U% A0 a& X7 ?5 E+ b, E1.4 Peptide binding5 P- g$ r& S$ A$ w$ D+ O& [3 i( N
Chapter 2: Immunoglobulins and B cell responses9 g5 v9 f- {/ x8 N# B
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2.1 Types of immunoglobulins( w i& O" c0 G- }$ V0 {" y% w
2.2 Immunoglobulin structure# {+ o' Y& W, ^ b4 I" p# ~' y" v
2.3 Immunoglobulin function
( Q6 g- t, Q9 t2 i: n" }2.4 Antigen binding3 O S/ [4 k% q- H
Chapter 3: Scientific publications and databases( } T2 m: m R7 S0 I
Abstract:% Q# q8 H- f) y
3.1 Bibliographical information
0 z% d2 `& z- P" j7 f \: m3.2 Searching the literature7 W: k) j5 }0 i( J6 }3 L- f
3.3 General databases containing information on genes and proteins1 J# F& {/ _: M+ u3 J
3.4 Immunological databases- @: ` r: b% B# O
3.5 Small molecule databases
: S4 { h' Q; l/ h4 {8 S, vChapter 4: Database design
& J3 R9 ]% j& D% y( l' T+ q2 _Abstract:4 A- t$ b8 b+ [$ _+ a: _6 q
4.1 Fundamentals of database design; U3 s: k5 P M& u1 Q4 P
4.2 ER diagram
8 {4 x+ E3 a3 G5 T4.3 Normalization and normal forms
# h5 L1 r# B- o$ p! bChapter 5: Computational T cell vaccine design
& Q9 e+ D4 h6 i xAbstract:
; \8 ]; b* ^$ ?& j1 b5.1 Sequence-based methods) @4 Q* K! U2 N9 l5 o, V0 K) }
5.2 Structure-based methods5 `* E2 [5 H. u) x# B
5.3 Broad-based T cell vaccine design, y3 _! B9 U" y1 B" a' x" m
Chapter 6: Computational B cell vaccine design4 L( D }8 X8 Z( ~0 g+ Q
Abstract:: F1 T- k" ?1 P- l6 O3 P; |
6.1 Sequence-based methods- R/ [: S, e, \) B' Z3 s
6.2 Structure-based methods
7 [% n* B- m4 @. k& p9 N' R, y. hChapter 7: Infectious disease informatics
( j' u2 x& e& ]0 L) E5 f6 cAbstract:$ E5 G h# V( h
7.1 Infectious diseases in history
/ L, `7 t5 P! X7 ^8 [7.2 Microbial sequence analysis! F* R, `" W0 X8 \7 q" X3 D/ H
7.3 Detecting natural selection in molecular evolution5 b$ K1 n( q+ h* t- o
Chapter 8: Vaccine safety and quality assessments G+ T7 b( N" t8 h' ~0 a6 g6 k. G
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8.1 Assessment of ADME/Tox deficiencies7 T0 H% X8 T/ ^; i1 `/ L
8.2 Assessment of allergenicity7 J' c2 S( X5 u& n
Chapter 9: Vaccine adjuvant informatics7 a1 m. m, ^/ p t6 f7 u& H) N
Abstract:
; d# _' X# a3 q) ]8 C0 \9.1 Virtual combinatorial library
7 Z- \4 n& v2 Q* v) U2 V+ m9.2 Chemical file formats
/ \- L; m9 l9 r' q- m0 r9.3 Considerations for virtual library design0 x9 e5 _, M c
Index3 P3 J& o% b' A% R9 Z& v' A. ?7 E
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