学习了，看帖回复是一种美德！

rojjer 发表于 2016-5-9 20:52
这种抗病毒思路如何进行?AHR是诱导型表达吗？

组成性表达的，AHR直接识别芳香烃类物质。有点奇怪的地方，我看我们组做的流感感染芯片中就会显著上调TIPARP分子，但是这篇文章中都加了AHR激动剂再做感染，流感应该还有某种机制激活AHR通路，有兴趣的可以试试啊

这种抗病毒思路如何进行?AHR是诱导型表达吗？

Constitutive aryl hydrocarbon receptor signaling constrains type I interferon–mediated antiviral innate defense

Taisho Yamada,        Hiromasa Horimoto,        Takeshi Kameyama,        Sumio Hayakawa,        Hiroaki Yamato, Masayoshi Dazai,        Ayato Takada,        Hiroshi Kida,        Debbie Bott,        Angela C Zhou,        David Hutin, Tania H Watts,        Masahiro Asaka,        Jason Matthews        & Akinori Takaoka

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic activity of many environmental xenobiotics. However, its role in innate immune responses during viral infection is not fully understood. Here we demonstrate that constitutive AHR signaling negatively regulates the type I interferon (IFN-I) response during infection with various types of virus. Virus-induced IFN-β production was enhanced in AHR-deficient cells and mice and resulted in restricted viral replication. We found that AHR upregulates expression of the ADP-ribosylase TIPARP, which in turn causes downregulation of the IFN-I response. Mechanistically, TIPARP interacted with the kinase TBK1 and suppressed its activity by ADP-ribosylation. Thus, this study reveals the physiological importance of endogenous activation of AHR signaling in shaping the IFN-I-mediated innate response and, further, suggests that the AHR-TIPARP axis is a potential therapeutic target for enhancing antiviral responses.

http://www.nature.com/ni/journal ... 422.html#affil-auth