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标题: 昆虫细胞表达人源化蛋白的综述 [打印本页]

作者: virology 时间: 2015-7-13 10:23
标题: 昆虫细胞表达人源化蛋白的综述
原贴由lijiang.bj 发表于 2010-7-27 10:22
http://biosky.haotui.com/thread-15788-1-2.html

Title：Developing baculovirus–insect cell expression systems for humanized recombinant glycoprotein production

Abstract：The baculovirus-insect cell expression system is widely used to produce recombinant glycoproteins for many different biomedical applications. However, due to the fundamental nature of insect glycoprotein processing pathways, this system is typically unable to produce recombinant mammalian glycoproteins with authentic oligosaccharide side chains. This minireview summarizes our current understanding
of insect protein glycosylation pathways and our recent efforts to address this problem. These efforts have yielded new insect cell lines and baculoviral vectors that can produce recombinant glycoproteins with humanized oligosaccharide side chains.
© 2003 Elsevier Science (USA). All rights reserved.

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