|
本帖最后由 randomqd 于 2016-8-16 12:20 编辑 1 Y1 m3 f+ _# z6 \! E% i& q9 q
* B+ Z3 ]0 t6 {# o, c4 X1st Edition7 M' L; |. V: _) w4 {8 L
Authors: Joo Chuan Tong Shoba Ranganathan
S. R' X3 a3 K" D2 r/ U" JElectronic ISBN 9781908818416 Print ISBN 9781907568411) @+ F' L8 E% P7 P
8 `) O8 t) R2 @& B: N3 FDescription
o1 u; v& |2 s/ z8 n0 PComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
4 Y4 G; E0 e" y, [Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
- t3 m8 y, u$ M: K4 p! L8 T2 d( z% S+ T' v% w
$ k7 U+ k3 F) b9 Y A* G0 J K1 q; @1 X
Table of Contents
' ^% F5 P, o! ^6 `6 T- R: V2 R" jList of figures e6 A* B* W4 D, N: k7 W
List of abbreviations
/ A( }0 h2 k' [8 R mAbout the authors8 C4 g" a* J& d9 a
Preface+ A6 S0 q% {; f6 Z m& e
Chapter 1: MHC and T cell responses, e8 {! _$ D8 k" S! d; \" N
Abstract:6 G9 X. H6 s) z4 a# V9 Z! o% H
1.1 Genetic organization of the MHC! {. Y6 Y. ^% A Z' I
1.2 MHC structure
0 c/ X" x8 a" U+ @- B1.3 MHC function
0 X4 K0 T5 ~* p1.4 Peptide binding
4 k% l3 U# f) I$ |# U) n" sChapter 2: Immunoglobulins and B cell responses9 g5 d0 T" t2 @5 f
Abstract:$ [# C6 B, e; q% A, n0 k% @
2.1 Types of immunoglobulins
5 X4 N3 `, a/ ^& a0 ~* j; Q, A2.2 Immunoglobulin structure
& N1 y7 x/ Q5 g6 {; F2.3 Immunoglobulin function
- m v; O. e' B4 q% ~2.4 Antigen binding- o6 H! l$ z& j3 e7 P* G
Chapter 3: Scientific publications and databases/ R. B; W/ F* c7 k
Abstract:
; x3 d& Y; @; |! N s& D4 V. b& v3.1 Bibliographical information& B3 `& L. d5 B3 m8 C
3.2 Searching the literature+ c$ J, Y0 D% U* S; f2 F( i1 R/ j
3.3 General databases containing information on genes and proteins! {% h. A. z2 O/ w8 S* i
3.4 Immunological databases
6 h' v3 E2 |6 O9 U3.5 Small molecule databases
- O$ [ L. g1 e% _Chapter 4: Database design
" d, P+ k* ^( @& j. c b. t- BAbstract:
( `3 A4 M. k6 O2 P$ `- M4.1 Fundamentals of database design
8 u- r" Z! |8 y; s5 r3 ?, b3 E9 |4.2 ER diagram$ |/ k7 Y1 H- N
4.3 Normalization and normal forms8 V1 |$ n3 U: E" L: S
Chapter 5: Computational T cell vaccine design
9 w$ R! n: E; o2 B) {& A' U& BAbstract:
1 \8 R* ~6 @( \+ z( @6 h5.1 Sequence-based methods" d. B& b3 s/ V2 a. t# d& _# \* w, F
5.2 Structure-based methods
+ D: b/ }- n% s! f9 T3 g1 J5.3 Broad-based T cell vaccine design
/ x: \) z0 w4 b& O+ eChapter 6: Computational B cell vaccine design
2 a4 U' ?5 H" p$ ^. a. W8 YAbstract:
! }' u8 T8 X/ A5 D* L1 I6.1 Sequence-based methods2 u! R" l1 ]1 J8 y& t, R. I
6.2 Structure-based methods
Z3 j9 g+ T2 JChapter 7: Infectious disease informatics V4 c2 ]. U, F3 {% ]
Abstract:5 q& m* A' k( d( F& w) f
7.1 Infectious diseases in history1 s6 x1 \1 n$ A1 {# @
7.2 Microbial sequence analysis# s& t, i$ y$ l+ Z! O, f
7.3 Detecting natural selection in molecular evolution
) X/ l$ U: b& t7 \/ A- |4 H4 rChapter 8: Vaccine safety and quality assessments7 C, U- n, D3 p+ x! d
Abstract:
! f( R E" E4 I# g+ n+ Q5 s* B8.1 Assessment of ADME/Tox deficiencies7 l$ D! n$ t& T2 x4 `
8.2 Assessment of allergenicity
$ r! L- I1 Y9 i q& E, ]. rChapter 9: Vaccine adjuvant informatics
9 N+ z, e( P7 {7 z5 X" m$ X2 z s. xAbstract:$ O% f7 H, V* Y. w; A
9.1 Virtual combinatorial library D* Q% O S. G4 A0 `
9.2 Chemical file formats
! A3 I. p4 C3 L M! ~+ {; Z6 z9.3 Considerations for virtual library design, [. W( [, g T0 H
Index
$ i$ a9 b3 Z" Q/ p0 x" M# k* [ s- j5 A8 f/ B7 b5 _
: s/ G7 p: c8 o9 T$ ^
5 r0 I. P, S7 g0 N' ]3 |0 T$ [原文下载地址:/ v$ k4 l2 r Z
. v5 u" J# ?4 m4 H1 R+ g5 Q2 |9 L
/ [3 V( u; G$ e3 ?% j |
本帖子中包含更多资源
您需要 登录 才可以下载或查看,没有帐号?立即注册
x
|