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本帖最后由 randomqd 于 2016-8-16 12:20 编辑
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1st Edition) D7 j6 q, j4 ^9 E+ U
Authors: Joo Chuan Tong Shoba Ranganathan
L2 e1 X2 f' d' Z1 Z* {+ Q" [Electronic ISBN 9781908818416 Print ISBN 9781907568411* c) C. k4 c8 G, D3 m
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Description
N: J# ~: |: N5 @* @# a$ w/ qComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
: [& I, f5 b1 \Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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Table of Contents. |$ ]( t# ], n% k; p
List of figures
# D( [' D( t# ~4 L8 e+ s2 C. RList of abbreviations
- \/ p( W$ E" lAbout the authors9 G4 v2 D, k, T. E; z
Preface+ O1 Z7 A6 [+ I
Chapter 1: MHC and T cell responses9 m w* Z) e$ Y8 o* q
Abstract:/ h% }- S( I: O y& H" C7 V
1.1 Genetic organization of the MHC
$ Y. R5 y% z% x" Y+ p/ ]1.2 MHC structure
& z1 n3 W" P& n) y8 o! v1.3 MHC function
* k$ W! P7 Z( t) g ^) ~6 \1 ^- G7 d1.4 Peptide binding) L2 a3 n; L- j/ \
Chapter 2: Immunoglobulins and B cell responses( R9 L( F5 T1 {; _' k
Abstract:' K8 E/ S4 ~+ Z) N; n/ X5 R5 M
2.1 Types of immunoglobulins: j# i1 s1 p: f6 ~
2.2 Immunoglobulin structure
I4 p, |$ r: [, @2.3 Immunoglobulin function
# F+ @4 q. {6 J" a( {2.4 Antigen binding
1 G3 Y; N2 [ o) s! X: DChapter 3: Scientific publications and databases3 C( `- L4 b- p: a5 k. c/ ]
Abstract:
8 a: o+ u7 F; j0 c; e3.1 Bibliographical information& ?5 Q; B- \/ }& }
3.2 Searching the literature C: f& O7 r3 p/ k; v) K
3.3 General databases containing information on genes and proteins9 B. o. M" W3 a) R
3.4 Immunological databases7 ]9 R& b+ T/ f6 T0 }
3.5 Small molecule databases; a `, f$ x# ~; E4 x* L' l. I
Chapter 4: Database design- F; l1 r# o+ k% v' v9 T, F6 V+ l
Abstract:( Z0 h$ ^2 V, c3 w
4.1 Fundamentals of database design
8 }$ M7 z' h- X8 h) C4.2 ER diagram- ]: ]# k! t% H/ w9 |* J
4.3 Normalization and normal forms
4 J1 _5 a- r' q! T5 yChapter 5: Computational T cell vaccine design$ D! p1 v6 `$ L1 k
Abstract:
# _- u$ m Y/ `5 U H7 ` F5.1 Sequence-based methods5 r( V2 A* q3 c, ?5 d
5.2 Structure-based methods
6 [. y( ^- m- B0 r0 Y5 P5 H, r" P5.3 Broad-based T cell vaccine design0 ?) j2 ?* \% d2 r5 O2 b1 C
Chapter 6: Computational B cell vaccine design4 h* f! [: l9 X# y- D
Abstract:
+ G- ~$ v3 a4 ~) V/ _- e/ y6.1 Sequence-based methods4 \$ Y+ K$ y0 i. w4 H- _( @! l
6.2 Structure-based methods- |* ], K" }4 X" A% Z7 ?3 P
Chapter 7: Infectious disease informatics* W2 ?& n" h, f# }" f
Abstract:
, }( G) {. N, w, h+ c/ n7.1 Infectious diseases in history( Q1 Q" Y0 R: r3 q
7.2 Microbial sequence analysis0 F: q5 C3 d2 D' {& P
7.3 Detecting natural selection in molecular evolution& F7 t0 @. ~' w# F( U+ J
Chapter 8: Vaccine safety and quality assessments
8 {% `5 x K5 F& {) T9 MAbstract:
* A) x1 ]7 U( L" e3 S8.1 Assessment of ADME/Tox deficiencies/ |. y; C" v' W
8.2 Assessment of allergenicity! @6 [9 r/ t7 c4 `( L. A
Chapter 9: Vaccine adjuvant informatics3 e+ B& Z& J q1 ^& s& C
Abstract:
/ o, G/ k8 [% Y) R" ]9.1 Virtual combinatorial library2 Y4 d' Z& g T# N
9.2 Chemical file formats
& E+ y, x$ G, R; a- y2 i& s9.3 Considerations for virtual library design/ |" L8 k; S! Z3 a
Index0 ]5 C$ R4 f5 |7 d, _. n/ ?9 S
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