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#Rojjer
谢谢,蜗牛兄的补充!我不知道IgA也具有ADE作用是不是首先就在HIV研究中发现的。
High prevalence of serum IgA HIV-1 infection-enhancing antibodies in HIV-infected persons. Masking by IgG
PA Kozlowski, KP Black, L Shen and S Jackson
Department of Microbiology, University of Alabama at Birmingham 35294, USA.
Enhanced HIV infection by IgA was observed most often at concentrations equivalent to serum dilutions in the range 10(-3) to 10(-5) and could be inhibited by preincubation of U937 cells with a mAb specific for the Fc alpha receptor. Concentrations of IgG mediating ADE were generally present in sera at dilutions from 10(-4) to 10(-6).…… |
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