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标题: [转移贴]Pymol Course materials 2011 首发！！ [打印本页]

作者: hantavirus 时间: 2015-6-8 14:22
标题: [转移贴]Pymol Course materials 2011 首发！！
原贴由donggua 发表于 2011-11-28 16:08

Structural Biology Exercise #1 Insulin

GOALS OF THE PRACTICAL:
1. To learn to look for a structure databank code from a structure paper
2. To get familiar with Pymol, which is used for visualisation of protein structures
3. To learn how Insulin was modified to make it act faster

01_Exercise_insulin.pdf (212.69 KB, 下载次数: 253)

Structural Biology Exercise #2
“Function of Non-steroidal Anti-inflammatory Drugs”

GOALS OF THE PRACTICAL:
1. Get familiar with proteopedia, protein data bank and pymol
2. How to find information about the structure
3. How to visualize and compare structures

02_aspirin_practical.pdf (319.68 KB, 下载次数: 239)

Structural Biology Exercise #3
Why are statins powerful inhibitors of cholesterol synthesis?”

GOALS OF THE PRACTICAL:
1. Get more familiar with proteopedia, protein data bank and pymol
2. How to find information about the structure
3. How to analyze protein-ligand interactions

03_Exercise_Statin.pdf (84 KB, 下载次数: 257)

Structural Biology Exercise #4:
Lysosomal α-mannosidase: several inherited ways to fall

Lysosomal α-mannosidase (LAM) is a protein, which breaks oligomeric mannose sugars released from degraded proteins, into single mannose sugars. Failure in LAM function results in a severe inherited disease, α-mannosidosis. Several inherited missense mutations are known, which result in α-mannosidosis in man, cat or cattle. We will now look at a few of these. The structure of the bovine LAM is known from the bovine enzyme. The sequence of the bovine enzyme is 80% identical to the sequence of the human enzyme, so we can use the bovine LAM structure as such to look at the mutations in the human LAM.

04_Excersize_mannosidase.pdf (178.82 KB, 下载次数: 270)

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