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标题: 求帮忙下这篇文献 [打印本页]
作者: zszhao    时间: 2015-11-17 22:50
标题: 求帮忙下这篇文献
http://www.nature.com/ni/journal/v13/n6/full/ni.2301.html顺便下一下补充的pdf
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作者: marine0425030    时间: 2015-11-18 09:34
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
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Di Wang,        Mingzhu Zheng,        Lei Lei,        Jian Ji,        Yunliang Yao,        Yuanjun Qiu,        Lie Ma,        Jun Lou,        Chuan Ouyang,        Xue Zhang,        Yuewei He,        Jun Chi,        Lie Wang,        Ying Kuang,        Jianli Wang,        Xuetao Cao        & Linrong Lu
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8 E  e. s4 w$ d. u! bSignaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.: R* d* @3 |3 z* }/ v

% B% Y# I7 V& ~1 \3 S, `7 t鲁教授又出好文章了。
作者: ipsvirus    时间: 2015-11-18 11:04
文件有点大，留个邮箱吧，我发你
作者: zszhao    时间: 2015-11-19 13:09
ipsvirus 发表于 2015-11-18 11:04% X# X% r+ J+ U
文件有点大，留个邮箱吧，我发你

7 k9 J- n' x4 |1455710563@qq.com，谢谢啦
作者: zszhao    时间: 2015-11-19 13:09
marine0425030 发表于 2015-11-18 09:34
5 F& @2 y( G! ~3 o+ _2 N8 \Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling, f1 I) T3 z, l$ T: m( T
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  ...
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未来的老板
作者: ipsvirus    时间: 2015-11-19 13:17
zszhao 发表于 2015-11-19 13:09
% v' a/ H7 }. L6 |8 H# \( O，谢谢啦

9 P+ I2 V8 I+ L- d) ]8 z. Q, ]已发，请查收



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