John Taylor 一个做HDV领军级人物
Research InterestsHuman hepatitis delta virus (HDV) is an infectious agent found in nature only in association with hepatitis B virus (HBV). In fact, HDV is less than a virus in that it needs help from HBV to carry out a cycle of replication. Our efforts are directed towards understanding the structure and replication of HDV, and the nature of its interactions with HBV.
Rotation Projects
Currently there are two main research areas in this lab. Both are concerned hepatitis delta virus (HDV), a subviral agent that replicates using the envelope proteins of hepatitis B virus (HBV) as a helper virus.
The first area addresses how the small circular RNA genome of HDV can be copied by redirection of the host RNA polymerase II. This seemingly unique situation has wider implications in that we are trying to understand how RNA molecules either act as templates or are inhibited from acting as templates for host RNA polymerases.
The second area concerns how HDV is assembled into virus particles and how these infect primary human hepatocytes, the normal and restricted host cell for this virus. The wider significance of these studies is that we are at the same time obtaining information that also applies to HBV. That is, we are determining how HBV is able to attach to and infect susceptible cells. This is a major unsolved question for what is the major cause worldwide of chronic liver disease and hepatocellular carcinoma.
现在他们实验室人员:
John Taylor - Senior Member (Fox Chase Cancer Center) and Adjunct Assoc. Prof. (U. of Penn)
Severin Gudima - Research Associate
Ziying Han - Research Associate
Ning Chai - Postdoctoral Fellow
Xingcao Nie - Postdoctoral Fellow
Ho Eun Chang - Graduate Student
发表文章:
Taylor, J.M., Farci, P., Purcell, R.H. Hepatitis delta virus. In Fields Virology, eds. Knipe and Howley, Lippincott, Williams & Wilkins, 2007, pp. 3031-3046..
Gudima, S., He, Y., Meier, A., Chang, J., Chen, R., Jarnik, M., Nicolas, E., Bruss, V., Taylor, J. Assembly of hepatitis delta virus: particle characterization including ability to infect primary human hepatocytes. J. Virol., 81: 3607-3617, 2007.
Gudima, S., Meier, A., Dunbrack, R., Taylor, J., Bruss, V. Two potentially important elements of the hepatitis B virus large envelope protein are dispensable for the infectivity of hepatitis delta virus.J. Virol. 81: 4343-4347, 2007.
Chai, N., Gudima, S., Chang, J., Taylor, J. Immunoadhesins containing pre-S domains of hepatitis B virus large envelope protein are secreted and inhibit virus infection. J. Virol., 81: 4912-4918, 2007.
Chai, N., Gudima, S., Chang, H., Chang, J., Taylor, J. Hepatitis B virus envelope proteins can be assembled onto a lentivirus vector that specifically and efficiently infects primary human hepatocytes. J. Virol., in press.[不过这篇文章有点问题]
http://www.med.upenn.edu/camb/faculty/mv/taylor.html
John M Taylor，Fox Chase Cancer Center，费城
乙肝复制
https://www.foxchase.org/john-taylor
Taylor, J. M. (2015). "Hepatitis D Virus Replication." Cold Spring Harb Perspect Med 5(11).
Taylor, J. M. (2014). "Host RNA circles and the origin of hepatitis delta virus." World J Gastroenterol 20(11): 2971-8.
Taylor, J. M. (2013). "Virus entry mediated by hepatitis B virus envelope proteins." World J Gastroenterol 19(40): 6730-4.
Taylor, J. M. (2012). "Virology of hepatitis D virus." Semin Liver Dis 32(3): 195-200.
Taylor, J. M. and Z. Han (2010). "Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virus." PLoS One 5(12): e15784.
Taylor, J. M. (2009). "Chapter 3. Replication of the hepatitis delta virus RNA genome." Adv Virus Res 74: 103-21.
Chang, J. and J. T. Guo, et al. (2008). "Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus innonhepatic cells." J Virol 82(16): 8215-23.
Taylor, J. M. (2006). "Structure and replication of hepatitis delta virus RNA." Curr Top Microbiol Immunol 307: 1-23.
Taylor, J. M. (2006). "Hepatitis delta virus." Virology 344(1): 71-6.
Gudima, S. O. and J. Chang, et al. (2006). "Restoration in vivo of defective hepatitis delta virus RNA genomes." RNA 12(6): 1061-73.
Chang, J. and S. O. Gudima, et al. (2005). "Evolution of hepatitis delta virus RNA genome following long-term replication incell culture." J Virol 79(21): 13310-6.
Chang, J. and S. O. Gudima, et al. (2005). "Development of a novel system to study hepatitis delta virus genome replication." J Virol 79(13): 8182-8.
Gudima, S. O. and J. Chang, et al. (2004). "Features affecting the ability of hepatitis delta virus RNAs to initiate RNA-directed RNA synthesis." J Virol 78(11): 5737-44.
Nie, X. and J. Chang, et al. (2004). "Alternative processing of hepatitis delta virus antigenomic RNA transcripts." J Virol 78(9): 4517-24.
Chang, J. and A. Lerro, et al. (2004). "Hepatitis delta virus transfection for the mouse in vivo model." Methods Mol Med 96: 343-49.
Chang, J. and P. Provost, et al. (2003). "Resistance of human hepatitis delta virus RNAs to dicer activity." J Virol 77(22): 11910-7.
Chang, J. and J. M. Taylor (2003). "Susceptibility of human hepatitis delta virus RNAs to small interfering RNA action." J Virol 77(17): 9728-31.
Taylor, J. M. (2003). "Replication of human hepatitis delta virus: recent developments." Trends Microbiol 11(4): 185-90.
Taylor, J. M. (1999). "Human hepatitis delta virus: an agent with similarities to certain satellite RNAs of plants." Curr Top Microbiol Immunol 239: 107-22.
Taylor, J. M. (1999). "Replication of human hepatitis delta virus: influence of studies on subviral plant pathogens." Adv Virus Res 54: 45-60.
Taylor, J. M. (1999). "Hepatitis delta virus." Intervirology 42(2-3): 173-8.
Wu, T. T. and H. J. Netter, et al. (1997). "Effects of nucleotide changes on the ability of hepatitis delta virus to transcribe, process, and accumulate unit-length, circular RNA." J Virol 71(7): 5408-14.
Bichko, V. V. and J. M. Taylor (1996). "Redistribution of the delta antigens in cells replicating the genome of hepatitis delta virus." J Virol 70(11): 8064-70.
Bichko, V. V. and S. M. Lemon, et al. (1996). "Epitopes exposed on hepatitis delta virus ribonucleoproteins." J Virol 70(9): 5807-11.
Bichko, V. V. and Y. E. Khudyakov, et al. (1996). "A novel form of hepatitis delta antigen." J Virol 70(5): 3248-51.
Wu, T. T. and V. V. Bichko, et al. (1995). "Hepatitis delta virus mutant: effect on RNA editing." J Virol 69(11): 7226-31.
Lazinski, D. W. and J. M. Taylor (1995). "Regulation of the hepatitis delta virus ribozymes: to cleave or not to cleave?" RNA 1(3): 225-33.
Lazinski, D. W. and J. M. Taylor (1995). "Intracellular cleavage and ligation of hepatitis delta virus genomic RNA: regulation of ribozyme activity by cis-acting sequences and host factors." J Virol 69(2): 1190-200.
Netter, H. J. and T. T. Wu, et al. (1995). "Nucleotide sequence stability of the genome of hepatitis delta virus." J Virol 69(3): 1687-92.
Netter, H. J. and J. L. Gerin, et al. (1994). "Apparent helper-independent infection of woodchucks by hepatitis delta virus andsubsequent rescue with woodchuck hepatitis virus." J Virol 68(9): 5344-50.
Lazinski, D. W. and J. M. Taylor (1994). "Expression of hepatitis delta virus RNA deletions: cis and trans requirements for self-cleavage, ligation, and RNA packaging." J Virol 68(5): 2879-88.
Lazinski, D. W. and J. M. Taylor (1994). "Recent developments in hepatitis delta virus research." Adv Virus Res 43: 187-231.
Netter, H. J. and K. Kajino, et al. (1993). "Experimental transmission of human hepatitis delta virus to the laboratory mouse." J Virol 67(6): 3357-62.
Lazinski, D. W. and J. M. Taylor (1993). "Relating structure to function in the hepatitis delta virus antigen." J Virol 67(5): 2672-80.
Taylor, J. M. (1992). "The structure and replication of hepatitis delta virus." Annu Rev Microbiol 46: 253-76.
Mason, W. S. and J. M. Taylor (1991). "Liver transplantation: a model for the transmission of hepatitis delta virus." Gastroenterology 101(6): 1741-3.
Taylor, J. M. (1991). "Human hepatitis delta virus." Curr Top Microbiol Immunol 168: 141-66.
Glenn, J. S. and J. M. Taylor, et al. (1990). "In vitro-synthesized hepatitis delta virus RNA initiates genome replication in cultured cells." J Virol 64(6): 3104-7.
Taylor, J. M. (1990). "Hepatitis delta virus: cis and trans functions required for replication." Cell 61(3): 371-3.
Mason, W. S. and J. M. Taylor (1989). "Experimental systems for the study of hepadnavirus and hepatitis delta virus infections." Hepatology 9(4): 635-45.
Petcu, D. J. and C. E. Aldrich, et al. (1988). "Suramin inhibits in vitro infection by duck hepatitis B virus, Rous sarcoma virus, and hepatitis delta virus." Virology 167(2): 385-92.
Molnar-Kimber, K. L. and J. Summers, et al. (1983). "Protein covalently bound to minus-strand DNA intermediates of duck hepatitis B virus." J Virol 45(1): 165-72.
Mason, W. S. and C. Aldrich, et al. (1982). "Asymmetric replication of duck hepatitis B virus DNA in liver cells: Free minus-strand DNA." Proc Natl Acad Sci U S A 79(13): 3997-4001.
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